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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK2
All Species:
27.88
Human Site:
T290
Identified Species:
38.33
UniProt:
P24941
Number Species:
16
Phosphosite Substitution
Charge Score:
0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P24941
NP_001789.2
298
33930
T290
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
Chimpanzee
Pan troglodytes
XP_523720
325
36841
E310
H
P
Y
F
S
S
P
E
P
S
P
A
A
R
Q
Rhesus Macaque
Macaca mulatta
XP_001113345
298
33812
T290
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
G
Dog
Lupus familis
XP_856049
298
33839
T290
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
Cat
Felis silvestris
Mouse
Mus musculus
P97377
346
38960
T338
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
Rat
Rattus norvegicus
Q63699
298
33869
T290
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P13863
303
34670
D291
H
P
Y
F
D
D
L
D
K
S
T
L
P
A
N
Frog
Xenopus laevis
P23437
297
33852
S290
H
P
F
F
R
D
V
S
R
P
T
P
H
L
I
Zebra Danio
Brachydanio rerio
NP_998571
298
34001
T290
H
R
F
F
R
D
V
T
M
P
V
P
P
L
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P23573
314
35870
V293
Y
F
R
N
V
Q
H
V
D
H
V
A
L
P
V
Honey Bee
Apis mellifera
XP_393450
299
34033
T289
H
P
Y
F
N
G
V
T
L
V
P
P
P
L
P
Nematode Worm
Caenorhab. elegans
P34556
332
38277
H309
N
A
K
K
A
L
V
H
P
Y
F
D
N
M
D
Sea Urchin
Strong. purpuratus
XP_790847
299
34142
K290
H
P
Y
F
K
D
V
K
M
V
P
P
P
R
L
Poplar Tree
Populus trichocarpa
XP_002306004
294
33768
H284
T
A
R
S
A
L
E
H
E
Y
F
K
D
I
G
Maize
Zea mays
P23111
294
33816
H284
T
A
R
Q
A
L
E
H
E
Y
F
K
D
L
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
H284
N
A
R
A
A
L
E
H
E
Y
F
K
D
L
G
Baker's Yeast
Sacchar. cerevisiae
P00546
298
34043
I291
I
S
A
R
R
A
A
I
H
P
Y
F
Q
E
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
69.8
99.6
98.9
N.A.
85.2
98.6
N.A.
N.A.
65.3
88.9
90.2
N.A.
62.7
69.9
56.9
75.9
Protein Similarity:
100
79.6
99.6
99.6
N.A.
85.8
99.6
N.A.
N.A.
77.8
94.9
94.9
N.A.
74.8
82.2
69.8
88.6
P-Site Identity:
100
20
93.3
100
N.A.
100
100
N.A.
N.A.
33.3
66.6
73.3
N.A.
6.6
46.6
6.6
40
P-Site Similarity:
100
33.3
93.3
100
N.A.
100
100
N.A.
N.A.
46.6
86.6
80
N.A.
13.3
53.3
26.6
53.3
Percent
Protein Identity:
66.4
66.7
N.A.
67.1
62.4
N.A.
Protein Similarity:
83.2
82.2
N.A.
81.5
79.1
N.A.
P-Site Identity:
0
6.6
N.A.
6.6
6.6
N.A.
P-Site Similarity:
13.3
13.3
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
24
6
6
24
6
6
0
0
0
0
12
6
6
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
6
53
0
6
6
0
0
6
18
0
6
% D
% Glu:
0
0
0
0
0
0
18
6
18
0
0
0
0
6
6
% E
% Phe:
0
6
42
65
0
0
0
0
0
0
24
6
0
0
0
% F
% Gly:
0
0
0
0
0
6
0
0
0
0
0
0
0
0
18
% G
% His:
65
0
0
0
0
0
6
24
6
6
0
0
36
0
0
% H
% Ile:
6
0
0
0
0
0
0
6
0
0
0
0
0
6
6
% I
% Lys:
0
0
6
6
6
0
0
6
36
0
0
18
0
0
0
% K
% Leu:
0
0
0
0
0
24
6
0
6
0
0
6
6
59
6
% L
% Met:
0
0
0
0
0
0
0
0
12
0
0
0
0
6
0
% M
% Asn:
12
0
0
6
6
0
0
0
0
0
0
0
6
0
6
% N
% Pro:
0
59
0
0
0
0
6
0
12
48
18
53
24
6
6
% P
% Gln:
0
0
0
6
30
6
0
0
0
0
0
0
6
0
6
% Q
% Arg:
0
6
24
6
18
0
0
0
6
0
0
0
0
12
30
% R
% Ser:
0
6
0
6
6
6
0
6
0
12
0
0
0
0
6
% S
% Thr:
12
0
0
0
0
0
0
42
0
0
12
0
0
0
0
% T
% Val:
0
0
0
0
6
0
59
6
0
12
42
0
0
0
6
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
6
0
24
0
0
0
0
0
0
24
6
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _